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KMID : 1150720160050030187
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Integrative Medicine Research
2016 Volume.5 No. 3 p.187 ~ p.197
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Function of specialized regulatory proteins and signaling pathways in exercise-induced muscle mitochondrial biogenesis
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Erlich Avigail T.
Tryon Liam D.
Crilly Matthew J.
Memme Jonathan M.
Moosavi Zahra S. Mesbah
Oliveira Ashley N.
Beyfuss Kaitlyn
Hood David A.
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Abstract
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Skeletal muscle mitochondrial content and function are regulated by a number of specialized molecular pathways that remain to be fully defined. Although a number of proteins have been identified to be important for the maintenance of mitochondria in quiescent muscle, the requirement for these appears to decrease with the activation of multiple overlapping signaling events that are triggered by exercise. This makes exercise a valuable therapeutic tool for the treatment of mitochondrially based metabolic disorders. In this review, we summarize some of the traditional and more recently appreciated pathways that are involved in mitochondrial biogenesis in muscle, particularly during exercise.
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KEYWORD
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mitochondrial protein import, PGC-1alpha, skeletal muscle, unfolded protein response
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